Triamcinolone acetonide (TA) injections are widely
used for tendinitis but have deleterious effects, including tendon degeneration
or tendon rupture.
To investigate whether adding platelet-rich plasma
(PRP), a blood fraction that participates in tissue repair processes, to TA can
prevent its deleterious effects.
Controlled laboratory study.
Rat Achilles tendons were injected with TA, TA + PRP,
PRP alone, or saline (control). Biomechanical testing and histological analyses
were performed on Achilles tendons 1 week after injections.
The maximum failure loads in the control, TA, TA +
PRP, and PRP groups were 31.7 ± 2.3, 19.0 ± 3.6, 31.0 ± 7.1, and 30.2 ± 6.8 N,
respectively. The tendon stiffness in the control, TA, TA + PRP, and PRP groups
was 12.1 ± 1.8, 7.5 ± 1.8, 11.0 ± 2.8, and 11.3 ± 2.5 N/mm, respectively. The
maximum failure load and stiffness were significantly lower in the TA group
compared with the other 3 groups. There was no significant difference between
the TA + PRP and control groups. Cell invasions, vacuolation, collagen
attenuation, and increased type III collagen expression were histologically observed
in the TA group; however, these changes were prevented by the simultaneous
administration of PRP.
Administering PRP may prevent deleterious effects
caused by TA; therefore, PRP may be used as a protective agent in clinical
PRP can be useful as a protective agent for sports
injury patients receiving local corticosteroid injections.